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NAD+ Repletion Rescues Female Fertility during Reproductive Aging
The research paper was done in 2020 by Harvard University and other institutions. It showed how NAD+ was able to rescue fertility in old mice and their pups were also able to reproduce.

Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
This research discusses NAD+ activation and cellular processes associated with Sirtuins that effect both male and female infertility.

Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest
This research was conducted in Japan and show how SIRT3, a NAD+ dependent gene is critical for fertilization and blastocyst development.

Mitochondrial Metabolism Modulation: A New Therapeutic Approach for Parkinson’s Disease
This research discuss how mitochondrial dysfunction is associated with neurodegeneration and Parkinson’s disease. It also discuss strategies to mitigate using NAD+ pathways for neural regeneration.

Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring
This research shows clear evidence in mice of NAD+ effects on offspring development, brain development and benefits to mothers that supplemented.

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
The above research paper for Harvard and David Sinclair outlines how NAD+ is used for Metaboic and cardiovascular disease.

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease
The below research paper modeled how NAD+ can rescue mitochondrial defects and neuron loss at the University of Cambridge.

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue
The above paper discusses how NAD+ declines as we age, and by 40 we have lost 50% of our NAD+.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
This paper discusses how NAD+ can be used to help with vascular aging as it is NAD+ dependent.

Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
This research paper discuss Type 2 diabetes and how NAD+ biosynthesis is crtical to the process as well as supplementation outcomes.

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
This research paper clearly shows the mechanism for endothelial aging and also how NAD+ plays a crucial role in this difficult and deadly condition.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Ageing
This research paper clearly shows the mechanism for endothelial aging and also how NAD+ plays a crucial role in this difficult and deadly condition.

H2S to Mitigate Vascular Aging: A SIRT1 Connection
The Buck Institute in the USA and National University of Singapore collaborated to study the effects of NAD+ and the role of Sirt1 in vascular aging.

Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson’s disease
This research discuss how NAD+ is neural protective and can support regeneration of neurons as well as mitochondrial heatlh.
Categories
- NAD+ (14)
- Stem Cells (6)
Popular Post
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Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19 posted on August 20, 2020
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NAD+ Repletion Rescues Female Fertility during Reproductive Aging posted on August 25, 2020
-
Leveraging Induced Pluripotent Stems Cell Technology, Researchers Control Diabetes in Mice posted on May 7, 2020

Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19
This study aims to review the outcomes of ongoing clinical studies on stem cells in Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS), and Middle East Respiratory Syndrome (MERS). The results will be associated with possible applications to COVID-19.

Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyper-responsiveness associated with chronic allergic airways disease
The above paper was done in Australia showing how iPSC MSC can be use to repair lung tissues and airwasy in 2017.

Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo- Controlled Clinical Trial
The above paper was done in the USA using umbilical cord stem cells to show clinically the benefits of stem cells for Aging Fraility in 2017.

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose
and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
The above paper show how umbilcial cord stem cells greatly improve Osteoarthritis and reduces pain in a clinical study in 2018.

Leveraging Induced Pluripotent Stems Cell Technology, Researchers Control Diabetes in Mice
“The generation of glucose-responsive islet-like organoids that are able to avoid immune detection provides a promising alternative to cadaveric and device-dependent therapies in the treatment of diabetes.” Evans further suggested, “We now have a product that could potentially be used in patients without requiring any kind of device.”

Advances in Cell Line Development for Neurodegenerative Diseases
“The current and future clinical applications of cell lines are bountiful,” Dr Feldman concluded, a sentiment echoed by Dr Reubinoff, who stated, “It is becoming increasingly essential to consider GMP compliance, safety, and regulatory criteria as stem cell lines become poised for clinical applications.”
Categories
- NAD+ (14)
- Stem Cells (6)
Popular Post
-
Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19 posted on August 20, 2020
-
NAD+ Repletion Rescues Female Fertility during Reproductive Aging posted on August 25, 2020
-
Leveraging Induced Pluripotent Stems Cell Technology, Researchers Control Diabetes in Mice posted on May 7, 2020