The research paper was done in 2020 by Harvard University and other institutions. It showed how NAD+ was able to rescue fertility in old mice and their pups were also able to reproduce.

This research discusses NAD+ activation and cellular processes associated with Sirtuins that effect both male and female infertility.

This research was conducted in Japan and show how SIRT3, a NAD+ dependent gene is critical for fertilization and blastocyst development.

This research discuss how mitochondrial dysfunction is associated with neurodegeneration and Parkinson’s disease. It also discuss strategies to mitigate using NAD+ pathways for neural regeneration.

This research shows clear evidence in mice of NAD+ effects on offspring development, brain development and benefits to mothers that supplemented.

The above research paper for Harvard and David Sinclair outlines how NAD+ is used for Metaboic and cardiovascular disease.

The below research paper modeled how NAD+ can rescue mitochondrial defects and neuron loss at the University of Cambridge.

The above paper discusses how NAD+ declines as we age, and by 40 we have lost 50% of our NAD+.

This paper discusses how NAD+ can be used to help with vascular aging as it is NAD+ dependent.