Cardiovascular disease is a leading cause of death in the developed world. Strategies to address this are now being researched and the use of NAD+ in animal models is proving to be very beneficial and clinical outcomes for certain indications are showing great promise.
Two specific areas that are of particular interest are vascular aging and also cardiac conditions such as arrythmias. Mouse knock out models using genetically modified animals have shown that supplementation using NAD+ can be very beneficial for these conditions and improvements have been documented in published peer reviewed research papers at such prestigious institutions as Harvard University and the Buck Institute on Aging in the United State
The human genome has been sequenced and epigenetics can now show how substances can turn on and turn off genes ( SIRTUIN 1-7 ) . This allow for scientist to prove if a compound is having the desired metobolic effect on diseases like cardiovascular conditions and how these disease have been reversed in animal models. NAD+ shows great promise in this area as the literature clearly shows.
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
The below research paper from Harvard University outlines various conditions that can supported with NAD+ supplementation and is a solid overview of current science.
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
This research paper clearly shows the mechanism for endothelial aging and also how NAD+ plays a crucial role in this difficult and deadly condition.
H2S to Mitigate Vascular Aging: A SIRT1 Connection
The Buck Institute in the USA and National University of Singapore collaborated to study the effects of NAD+ and the role of Sirt1 in vascular aging.