NAD+ was first discovered in the early 1900s and is a metabolite of vitamin B or B3 specifically. It was used primarily orally then injected intramuscularly. It was not until the 1960 that is was purified into NAD+ and used clinically on patients on formal published peer reviewed clinical trials via intravenous application.

A pioneer in the use of NAD+ was Dr. Birkmeyer who was the inventor of the L-dopa protocol which he used in Parkinson’s patiets to help with mobility. His son George Birkmeyer then discovered if NAD+ was used to support these patients, they could achieve a far better clinical response and help many more patients.

Fast forward to today, and NAD+ is used for a variety of neruological conditions, including demenita, Alzheimer’s, brain fog, memory issue, mild and tramautic brain injury. Cognitive improvement is the most noted benefit patients report and research continues into these area with new papers being published every week. 

Logo– Neural Health

As we age, our mental abilities decline rapidly and there is little to offer as the causes are still being researched. One area that has shown a great deal of promise since the 1950s and Parkinson’s patients has been NAD+ supplementation. Research on this is available along with other conditions related to cognitive decline and tramautic brain injury.

Recent Studies

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

The below research paper modeled how NAD+ can rescue mitochondrial defects and neuron loss at the University of Cambridge.

Mitochondrial Metabolism Modulation: A New Therapeutic Approach for Parkinson’s Disease

This research discuss how mitochondrial dysfuntion is associated with neurodegeneration and Parkinson’s disease. It also discuss strategies to mitigate using NAD+ pathways for neural regeneratation.

Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson’s disease

This research discuss how NAD+ is neural protective and can support regeneration of neurons as well as mitochondrial heatlh.