The research paper was done in 2020 by Harvard University and other institutions. It showed how NAD+ was able to rescue fertility in old mice and their pups were also able to reproduce.

This research was conducted in Japan and show how SIRT3, a NAD+ dependent gene is critical for fertilization and blastocyst development.

This research discuss how mitochondrial dysfunction is associated with neurodegeneration and Parkinson’s disease. It also discuss strategies to mitigate using NAD+ pathways for neural regeneration.