The research paper was done in 2020 by Harvard University and other institutions. It showed how NAD+ was able to rescue fertility in old mice and their pups were also able to reproduce.
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
This research discusses NAD+ activation and cellular processes associated with Sirtuins that effect both male and female infertility.
Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyper-responsiveness associated with chronic allergic airways disease
The above paper was done in Australia showing how iPSC MSC can be use to repair lung tissues and airwasy in 2017.
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo- Controlled Clinical Trial
The above paper was done in the USA using umbilical cord stem cells to show clinically the benefits of stem cells for Aging Fraility in 2017.
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose<br>and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial
The above paper show how umbilcial cord stem cells greatly improve Osteoarthritis and reduces pain in a clinical study in 2018.
Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest
This research was conducted in Japan and show how SIRT3, a NAD+ dependent gene is critical for fertilization and blastocyst development.
This research discuss how mitochondrial dysfunction is associated with neurodegeneration and Parkinson’s disease. It also discuss strategies to mitigate using NAD+ pathways for neural regeneration.
Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring
This research shows clear evidence in mice of NAD+ effects on offspring development, brain development and benefits to mothers that supplemented.
The above research paper for Harvard and David Sinclair outlines how NAD+ is used for Metaboic and cardiovascular disease.
The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease
The below research paper modeled how NAD+ can rescue mitochondrial defects and neuron loss at the University of Cambridge.
The above paper discusses how NAD+ declines as we age, and by 40 we have lost 50% of our NAD+.
This paper discusses how NAD+ can be used to help with vascular aging as it is NAD+ dependent.