The research paper was done in 2020 by Harvard University and other institutions. It showed how NAD+ was able to rescue fertility in old mice and their pups were also able to reproduce.

This research discusses NAD+ activation and cellular processes associated with Sirtuins that effect both male and female infertility.

This research was conducted in Japan and show how SIRT3, a NAD+ dependent gene is critical for fertilization and blastocyst development.